Genetic Masterpiece
UNIQUE
- All Mutants: Randomly start the fight with either +25% passive Attack Rating, +25% passive Power Rate, or +25% passive Armor Rating.
Mister Sinister
MutantReleased 2019
BHR reference
Every sig anchor × rank at A0. Sig levels in between interpolate smoothly (PCHIP) and round to the nearest 10 BHR — matching the in-game display.
| Sig | R3 | R4 | R5 |
|---|---|---|---|
| 0 | 19,340 | 23,620 | 28,010 |
| 20 | 21,710 | 26,490 | 31,430 |
| 40 | 22,520 | 27,490 | 32,610 |
| 60 | 23,200 | 28,330 | 33,600 |
| 80 | 23,820 | 29,070 | 34,490 |
| 100 | 24,380 | 29,760 | 35,300 |
| 120 | 24,900 | 30,390 | 36,050 |
| 140 | 25,390 | 30,990 | 36,770 |
| 160 | 25,860 | 31,570 | 37,450 |
| 180 | 26,310 | 32,120 | 38,100 |
| 200 | 26,750 | 32,650 | 38,730 |
BHR scaling
BHR at each signature level by rank (non-ascendable — A0 only). The curve is concave — sig 0 → 100 captures roughly two-thirds of the gain from sig 0 → 200.
Abilities
MCOCHUB ↗Immunities
Reverse Control ImmunityTaunt Immunity
Abilities
Bleed ResistanceBulwarkConcussionContact AttacksCrueltyDegenerationPower LeechRegenerationStun
Power Lock
Granted via synergy
Each time the opponent uses a Special Attack they become Power Locked for 6 seconds.
Tags
#AW : Provocateur#AW: Conduit#Control: Denial#Psychic Shielding#Size: L#Villain
ENGINEERED PERFECTION — Persistent Charge
- Each time Mister Sinister defeats an opponent, he extracts their genetic code, gaining a different Passive ability for the rest of the quest depending on the defeated Champion’s Class. [Max 3.0 of each Passive, 1000.0 Passives total.]
- Mister Sinister starts each fight with 3 of these effects at random. These do not persist between fights and do not count toward the max Passives.
- Mutant: Prowess, increasing Special Attack Damage by 9.9%.
- Skill: Precision, increasing Critical Rating by 4.9.
- Science: Regen Rate, increasing Regeneration Rate by 4.9%.
- Mystic: Combat Power Rate, increasing Power Rate by 4.9%.
- Cosmic: Fury, increasing Attack Rating by 9.9.
PASSIVES — via auntm.aiin-game text · frozen 2024
- Mister Sinister reduces the potency of incoming Bleed effects by 100%.
ALWAYS ACTIVE▾
- Mister Sinister’s Telepathic Mastery renders him Immune to Taunt and Reversed Controls.
- Mister Sinister reduces the potency of incoming Bleed effects by 100%.
- Mister Sinister’s Telekinetic Powers allow him to Block Unblockable Special Attacks, except against Tech Champions.
- Well-Timed Blocks grant a Bulwark Passive, increasing Block Proficiency by +10.0 for 10 seconds. Max: -1.
- Whenever a Skill Champion Purifies a Debuff, reduce the Ability Accuracy of their Purify Abilities by 2500.0%, up to -100%.
MOLECULAR REGENERATION — PASSIVE▾
- Regeneration Rate is increased by 1.0% for every hit on the opponent’s Combo Meter up to 5000.0 hits.
- Mister Sinister’s Regeneration Rate cannot be reduced.
- 100.0% chance to Regenerate 70.0% of damage dealt by enemy Critical Hits over 0.5 seconds. Abilities cannot modify the Ability Accuracy, Duration, or Potency of this ability, aside from effects that would modify Mister Sinister's Regeneration Rate.
WHILE CHARGING A HEAVY ATTACK▾
- Pauses the duration of Damaging Debuffs, Stun, Concussion, and Power Steal on the Opponent.
- Charging a Heavy Attack for 1 second grants a Vicious Passive, increasing the potency of Damaging Debuffs by 30% for 8 seconds.
- Charging a Heavy Attack for an additional 1 second triggers Mister Sinister's Genetic Manipulation. For the next 7 seconds, he inflicts a 10 second Bleed Debuff on himself every 0.7 seconds.
SPECIAL ATTACK 1▾
- Transfer all Damaging Debuffs on Mister Sinister to non-#Robot Opponents, converting them into Degeneration Debuffs dealing 90.0 Direct Damage over 6 seconds. This ability activates even if this attack is Blocked or avoided.
- Mister Sinister inflicts himself with a non-stacking 0 potency Bleed Debuff for 20 seconds.
SPECIAL ATTACK 2▾
- 100.0% chance to inflict Concussion, reducing the opponent’s Ability Accuracy by -100.0% for 6 seconds. This ability activates even if this attack is Blocked or avoided.
Team synergies(4)
Mutant Dominion
UNIQUE
- All Mutants: Gain +20% Passive Fury when fighting with Class Disadvantage.
Bloodlines
UNIQUE
- Mister Sinister, Cyclops (Blue Team), Cyclops (New xavier School), Phoenix: Special Attacks have +20% Critical Rating and gain True Strike, ignoring all Armor, Resistances, Evasion, and Auto Block.
Masterminds
UNIQUE
- Mister Sinister, Kingpin, Ultron, M.O.D.O.K.: Each time the opponent uses a Special Attack they become Power Locked for 6 seconds.
You enable for other champions(13)
Bringing this champion enables the following synergies for other champions in your team. The host's effect text is shown so you can see what benefit the pairing unlocks.
Your Fate Is Mine
UNIQUEBenefit for Apocalypse
- Apocalypse: Start the first fight in a quest with maximum Genetic Code.
- Kang: Every 4 seconds, Kang Gains an indefinite Fury Buff granting 20% Attack Rating. This ends when reaching 20 stacks of Fury.
- Mister Sinister: Degeneration Debuffs gain +50% Potency.
- Cable: Incinerate Debuffs gain +150% Potency. Additionally, Heavy Attacks now inflict Degeneration on each hit and their stack limit is removed.
Geneticists
UNIQUEBenefit for Arnim Zola
- Arnim Zola: Personal Disintegration Debuffs deal 20% more damage.
- Mister Sinister: Personal Degeneration Debuffs deal 20% less damage but gain 50% increased duration.
Enemies
Benefit for Colossus
- All Champions gain +[155] Critical Rating.
Peak Fashion
UNIQUEBenefit for Count Nefaria
- Synergy Champions: Block Proficiency increased by +[400].
Enemies
Benefit for Gambit
- All Champions gain +[155] Critical Rating.
Runs in the Family
UNIQUEBenefit for Havok
- Havok: Gain 2 Plasma Charge(s) after each Special Attack.
- Mister Sinister: Well timed Blocks against contact attacks inflict Degeneration, dealing 30% of Attack as Direct Damage over 1 second(s).
- Cyclops (Blue Team), Cyclops (New Xavier School): Armor Break effects increase their Duration by 100%.
Rivals
Benefit for Kingpin
- All Champions gain +[115] Critical Damage Rating.
Crazy Scientists
UNIQUEBenefit for Lizard
- Lizard: Personal Unstoppable lasts +2 seconds.
- M.O.D.O.K.: At the end of Special 1, inflict a non-stacking 100% Petrify Debuff for 4 seconds.
- Mister Sinister: When the Opponent fails to Purify one or more Debuffs due to reduced Ability Accuracy, self-inflict a personal Bleed Debuff.
- The Overseer: Against Mystic Champions, gain a Steadfast Passive while at or above 3 Gamma Power.
The Monster Who Created Me
UNIQUEBenefit for Madelyne Pryor
- Synergy Champions: For each Madelyne Pryor on the team, inflict a 20% Hinder Debuff for 3 seconds at the start of each fight.
No More Patients
UNIQUEBenefit for Sauron
- Sauron, Mister Sinister, Doctor Strange: Whenever an Opponent heals, gain a 2% Regen Passive for 2 seconds. This goes on Cooldown for 5 seconds. Once this has been triggered 4 times, Inflict Heal Block Passive for 12 seconds.
Enemies
Benefit for Storm
- All Champions gain +[155] Critical Rating.
Enemies
Benefit for Stryfe
- All Champions gain +[155] Critical Rating.
Intelligencia Old and New
Benefit for The Leader
- All Champions gain 5% Perfect Block Chance.
Sources
- BHR curves
- mcoc.gg per-rank curves (R4 + R5 11-anchor, refreshed 2026-06-03)
- Ascendable flag
- non-ascendable per mcoc.gg
- Last verified
- 2026-06-03
- Verify externally
- Fandom wiki ↗MCOCHUB prestige ↗mcoc.gg ↗